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Frequently Asked Questions

Although your doctor is the best source for answering your specific questions about treatment with ZYVOX, you can find answers to common questions here.

General Information About ZYVOX


What is ZYVOX?

ZYVOX is an oxazolidinone-class antibacterial indicated in adults and children for the treatment of the following infections caused by susceptible Gram-positive bacteria: Nosocomial pneumonia; Community-acquired pneumonia; Complicated skin and skin structure infections, including diabetic foot infections, without concomitant osteomyelitis; Uncomplicated skin and skin structure infections; Vancomycin-resistant Enterococcus faecium infections.

To reduce the development of drug-resistant bacteria and maintain the effectiveness of ZYVOX formulations and other antibacterial drugs, ZYVOX should be used only to treat infections that are proven or strongly suspected to be caused by bacteria.

How to Get Brand-Name ZYVOX


How can I ensure that I won’t get switched to a generic substitute?

Here are 3 suggested tips to help make sure you receive brand-name ZYVOX and not a generic:

  1. At your doctor’s office: Ask your doctor to prescribe brand-name ZYVOX and to indicate “DAW” (Dispense As Written)—or the language used in your state—on your ZYVOX prescription.
  2. At your pharmacy’s drop-off: Tell the pharmacist that you want brand-name ZYVOX—and be sure to use the ZYVOX Coupon. The ZYVOX Coupon can only be used with brand-name ZYVOX.
  3. At your pharmacy’s pick-up: Check your pills to be sure they’re brand-name ZYVOX—not the generic—and also check that you’ve saved on your prescription.

What should I do if I receive a generic substitute instead of brand-name ZYVOX?

Talk to your doctor and/or your pharmacist to ask if you should be getting brand-name ZYVOX.

How do I know if I received brand-name ZYVOX?

Check your pills for the distinctive shape and markings of brand-name ZYVOX.

Saving on ZYVOX


What is the ZYVOX Coupon?

The single-use ZYVOX Coupon allows eligible patients to pay as little as $1 and save up to $1,000 in out-of-pocket costs.*

*Terms and conditions apply.

How do I use the ZYVOX Coupon?

There are 2 ways to use the coupon immediately.

  • Bring a printed copy of it to the pharmacy
  • Show it to your pharmacist on your phone

Who is eligible to use the ZYVOX Coupon?

To be eligible to use a ZYVOX coupon, you must:

  • Be 18 years of age or older
  • Not be a resident of Massachusetts (Restrictions may apply in other states)
  • Not be covered by Medicare, Medicaid, or any other federal or state healthcare programs

The Card is not valid for California residents whose prescriptions are covered in whole or in part by third-party insurance, a healthcare service plan, or other health coverage where a lower cost generic is available, unless applicable step therapy or prior authorization requirements have been completed.

Please check with your healthcare professional or insurer to confirm eligibility.

To learn the full details of who is eligible, please see the full Terms and Conditions.

How do I get a ZYVOX Coupon?

To download a coupon, click here.

Can I use the ZYVOX Coupon on a previously filled prescription?

No, the ZYVOX Coupon can not be used on a previously filled prescription.

Taking ZYVOX


What should I avoid while taking ZYVOX?

Large quantities of foods or beverages with high tyramine content should be avoided while taking ZYVOX. Foods high in tyramine content include those that may have undergone protein changes by aging, fermentation, pickling, or smoking to improve flavor, such as aged cheeses, fermented or air-dried meats, sauerkraut, soy sauce, tap beers, and red wines. The tyramine content of any protein-rich food may be increased if stored for long periods or improperly refrigerated.

How should I store my ZYVOX?

Store at 25°C (77°F). Protect from light and keep bottles tightly closed to protect from moisture.

What should I know about taking ZYVOX?

Antibacterial drugs including ZYVOX should only be used to treat bacterial infections. They do not treat viral infections (e.g., the common cold). When ZYVOX is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. Skipping doses or not completing the full course of therapy may (1) decrease the effectiveness of the immediate treatment and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by ZYVOX or other antibacterial drugs in the future.

Safety & Possible Side Effects


Who should not take ZYVOX?

Do not take ZYVOX if you have a known hypersensitivity to linezolid or any of the other ingredients in ZYVOX.

Do not take ZYVOX if you are taking any monoamine oxidase inhibitors (MAOI) or within two weeks of taking an MAOI.

What are the most common side effects of ZYVOX?

The most common side effects include diarrhea, vomiting, headache, nausea, and anemia.

Diarrhea is a common problem caused by antibiotics, which usually ends when the antibiotic is discontinued. Sometimes after starting treatment with antibiotics, patients can develop watery and bloody stools (with or without stomach cramps and fever) even as late as two or more months after having taken the last dose of the antibiotic. If this occurs, you should contact your physician as soon as possible.

What should I tell my doctor before taking ZYVOX?

Before you take ZYVOX tell your doctor about all your medical conditions, including:

  • If you have a history of hypertension
  • If you are taking medications containing pseudoephedrine HCl or phenylpropanolamine HCl, such as cold remedies and decongestants
  • If you are taking serotonin re-uptake inhibitors or other antidepressants
  • If you experience changes in vision
  • If you have a history of seizures
  • If you have diabetes mellitus

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